病因・病態解析部門

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学会発表、講演活動、研究費など

国際学会| 国内学会

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論文

2018

Oka T, Mizuno H, Sakata M, Fujita H, Yoshino T, Yamano Y, Utsumi K, Masujima T, Utsunomiya A.
Metabolic abnormalities in adult T-cell leukemia/lymphoma and induction of specific leukemic cell death using photodynamic therapy.
Scientific Reports, 8:14979, 2018.new

Kuramitsu M, Okuma K, Nakashima M, Sato T, Sasaki D, Hasegawa H, Umeki K, Kubota R, Sasada K, Sobata R, Matsumoto C, Kaneko N, Tezuka K, Matsuoka S, Utsunomiya A, Koh KR, Ogata M, Ishitsuka K, Taki M, Nosaka K, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Okayama A, Miura K, Satake M, Saito S, Watanabe T, Hamaguchi I.
Value assignment of the reference material for human T-cell leukemia virus type 1 quantitative PCR in Japan.
Microbiol Immunol, 2018 Aug 20.new
doi: 10.1111/1348-0421.12644.

Sato T, Yamano Y.
Targeting human T-lymphotropic virus type 1-infected cells with an anti-C-C chemokine receptor 4 antibody in T-lymphotropic virus type 1-associated myelopathy.
Clinical and Experimental Neuroimmunology, 9(3):153-154, 2018.new

Nagasaka M, Abdallah N, Samantray J, Sukari A.
Is this really just “fatigue”? A case series of immune-related central adrenal insufficiency secondary to immune checkpoint inhibitors.
Clin Case Rep, 6:1278-1281, 2018.

Kawano N, Yoshida S, Kawano S, Kuriyama T, Tahara Y, Toyofuku A, Manabe T, Doi A, Terasaka S, Yamashita K, Ueda Y, Ochiai H, Marutsuka K, Yamano Y, Shimoda K, Kikuchi I.
The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1-associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation.
J Clin Exp Hematop, 2018 Aug 8.
doi: 10.3960/jslrt.18011.

Sato T, Yagishita N, Tamaki K, Inoue E, Hasegawa D, Nagasaka M, Suzuki H, Araya N, Coler-Reilly A, Hasegawa Y, Tsuboi Y, Takata A, Yamano Y.
Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Disease Activity.
Front Microbiol, 9:1651, Published online 25 July 2018.
doi: 10.3389/fmicb.2018.01651.

Hirano M, Jimbo K, Ogawa M, Ochi K, Makiyama J, Kawamata T, Yokoyama K, Tanaka T, Inamoto Y, Yamano Y, Fukuda T, Uchimaru K, Imai Y, Tojo A.
Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation Bone Marrow Transplantation.
Bone Marrow Transplantation, Published online 23 July 2018.
DOI: https://doi.org/10.1038/s41409-018-0202-9

Sukari A, Nagasaka M, Abdallah N.
Responses in patients receiving sequential paclitaxel post progression on PD1 inhibitors.
Oral Oncol, 80:100-102, 2018. 

Nagasaka M, Gadgeel SM.
Role of chemotherapy and targeted therapy in early-stage non-small cell lung cancer.
Expert Rev Anticancer Ther, 18(1):63-70, 2018.

Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y.
Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.
N Engl J Med, 378(6):529-538, 2018.

Shimizu J, Yamano Y, Yudoh K, Suzuki N.
Organ Involvement Pattern Suggests Subgroups within Relapsing Polychondritis.
Arthritis Rheumatol, 70(1):148-149, 2018.

山野嘉久, 山内淳司, 新谷奈津美, 八木下尚子, 佐藤知雄.
HTLV-1関連脊髄症(HAM)の病態・診断・治療.
神経内科, 89(3):297-303, 2018.new

森尾裕志, 大森圭貢, 井澤和大, 堅田紘頌, 石山大介, 小山真吾, 中尾陽光, 山野嘉久.
高齢入院患者におけるペットボトルの開栓に必要な握力.
専門リハビリ, 2018 in press.new

八木下尚子、山野嘉久.
希少難病HAMの患者レジストリを活用した治療薬開発への取り組みと展望
Jpn Pharmacol Ther (薬理と治療), 46(7):1113-1116, 2018.

2017

Sawada L, Nagano Y, Hasegawa A, Kanai H, Nogami K, Ito S, Sato T, Yamano Y, Tanaka Y, Masuda T, Kannagi M.
IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways.
PLOS Pathogen, 13(9):e1006597, 2017.

Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh K, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Okayama A, Miura K, Satake M, Saito S, Itabashi K, Yamaguchi K, Kuroda M, Watanabe T, Okuma K, and Hamaguchi I.
Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot analysis results.
Journal of Clinical Microbiology, 55(9):2838-2849, 2017.

Kawano N, Kuriyama T, Yoshida S, Kawano S, Yamano Y, Marutsuka K, Minato S, Yamashita K, Ochiai H, Shimoda K, Ishikawa F, Kikuchi I.
The Impact of a Humanized CCR4 Antibody (Mogamulizumab) on Patients with Aggressive-Type Adult T-Cell Leukemia-Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation.
J Clin Exp Hematop, 56(3):135-144, 2017.

Coler-Reilly ALG, Sato T, Matsuzaki T, Nakagawa M, Niino M, Nagai M, Nakamura T, Takenouchi N, Araya N, Yagishita N, Inoue E, Yamano Y.
Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study.
Neurotherapeutics, 14(4):1084-1094, 2017.

Terada Y, Kamoi K, Ohno-Matsui K, Miyata K, Yamano C, Coler-Reilly A, Yamano Y.
Treatment of rheumatoid arthritis with biologics may exacerbate HTLV-1-associated conditions: A case report.
Medicine (Baltimore), 96(6):e6021, 2017.

Willems L, Hasegawa H, Accolla R, Bangham C, Bazarbachi A, Bertazzoni U, Carneiro-Proietti AB, Cheng H, Chieco-Bianchi L, Ciminale V, Coelho-Dos-Reis J, Esparza J, Gallo RC, Gessain A, Gotuzzo E, Hall W, Harford J, Hermine O, Jacobson S, Macchi B, Macpherson C, Mahieux R, Matsuoka M, Murphy E, Peloponese JM, Simon V, Tagaya Y, Taylor GP, Watanabe T, Yamano Y. 
Reducing the global burden of HTLV-1 infection: An agenda for research and action. 
Antiviral Res, 137:41-48, 2017.

Yamano Y, Coler-Reilly A.
HTLV-1 induces a Th1-like state in CD4+ CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP.
Journal of Neuroimmunology, 304:51-55, 2017.

Yagishita N, Aratani S, Fujita H, Yamano Y, Nishioka K and Nakajima T.
Synoviolin is a Novel Pathogenic Factor of Arthropathy and Chronic Inflammattiion.
New Developments in the Pathogenesis of Rheumatoid Arthritis, 123-135/162, INTECH, February 22, 2017.

Yamano A, Yamano Y, Jacobson S.
Neuroimmunomodulation of Human T-Lymphotrophic Virus Type I/II Infection.
Neuroimmune Pharmacology, 421-436, 2017.

山野嘉久.
HTLV-1関連脊髄症に対するヒト化抗CCR4抗体療法開発の背景
神経治療学, 34(4):453-457, 2017.

山野嘉久.
HTLV-1関連脊髄症.
CareNet希少疾病ライブラリ, 2017.

八木下尚子、 山野嘉久.
HAM患者レジストリ「HAMねっと」によるリアルワールドデータの活用.
月刊PHARMSTAGE, 17(6):19-22, 2017.

八木下尚子、中島利博.
関節リウマチ発症因子 シノビオリン
アレルギーの臨床, 37(9):72-78, 2017.

山野嘉久.
HTLV-1関連脊髄症の診断と治療.
日本内科学会雑誌, 106(7):1404-1409, 2017.

新谷奈津美、山野嘉久.
HTLV-1関連脊髄症(HAM)の分子病態と治療
血液内科, 74(3):373-379, 2017.

2016

Shimizu J, Oka H, Yamano Y, Yudoh K, Suzuki N. 
Cutaneous manifestations of patients with relapsing polychondritis: an association with extracutaneous complications. 
Clin Rheumatol, 35(3):781-783, 2016.

Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K, Nakajima T.
Mitochondrial ubiquitin ligase activator of NF-kB regulates NF-kB signaling in cells subjected to ER stress.
Int J Mol Med, 37(6):1611-8, 2016.

Coler-Reilly ALG, Yagishita N, Suzuki H, Sato T, Araya N, Inoue E, Takata A, Yamano Y. 
Nation-wide epidemiological study of Japanese patients with rare viral myelopathy using novel registration system (HAM-net).
Orphanet Journal of Rare Diseases, 11(1):69, 2016.

Terao C, Yoshifuji H, Yamano Y, Kojima H, Yurugi K, Miura Y, Maekawa T, Handa H, Ohmura K, Saji H, Mimori T, Matsuda F.
Genotyping of relapsing polychondritis identified novel susceptibility HLA alleles and distinct genetic characteristics from other rheumatic diseases.
Rheumatology, 55(9):1686-1692, 2016.

Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.
HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors. 
J Neurovirol, 22(4):416-30, 2016.


八木下尚子、中島利博.
関節リウマチ発症因子シノビオリン.
アレルギーの臨床, 36(13):84-90,2016.

山野嘉久, 齋藤滋. 
HTLV-1.
産科と婦人科, 83(9):1021-1026, 2016. (2016年9月1日発行)

山野嘉久.
HTLV-1関連脊髄症の病態に基づいた疾患修飾薬の開発.
Modern Physician, 36(7):682-687, 2016.

新谷奈津美、佐藤知雄、アリエラ・コラライリー、八木下尚子、山野嘉久.
HTLV-1関連脊髄症(HAM)の分子病態解明による治療薬開発の新展開.
Jpn J Clin Immunol, 39 (3):207-212, 2016.

八木下尚子、中島利博.
関節リウマチ発症因子シノビオリン.
別冊BIO Clinica 慢性炎症と疾患, 5(3):137-143, 2016.

山野嘉久.
HAMに対するヒト化CCR4抗体の医師主導治験.
臨床評価, 43(2):418-421, 2016.

山野嘉久.
痙性対麻痺(HAMを含む).
今日の治療指針2016、山口 徹、北原光夫 監修.P964-965、医学書院、東京、2016.

2015

Martin F, Inoue E, Cortese ICM, de Almeida Kruschewsky R, Adonis A, Grassi MFR, Galvao-Castro B, Jacobson S, Yamano Y, Taylor GP, Bland M.
Timed walk as primary outcome measure of treatment response in clinical trials for HTLV-1-associated myelopathy: a feasibility study.
Pilot and Feasibility Studies 2015, 1:35, 2015.

Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H,  Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y.
Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy.
J Infect Dis, 211(2):238-248, 2015.

Bangham C, Taylor G, Yamano Y, Araujo A.
HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).
Nature Reviews Disease Primers, 1, 2015.

Yamano Y.
How does human T-lymphotropic virus type 1 cause central nervous system disease? The importance of cross-talk between infected T cells and astrocytes.
Clin Exp Neuroimmunol, 6(4):395-401, 2015.

Kuramitsu M, Okuma K, Yamochi T, Sato T, Sasaki D, Hasegawa H, Umeki K, Kubota R, Sobata R, Matsumoto C, Kaneko N, Naruse I, Yamagishi M, Nakashima M, Momose H, Araki K, Mizukami T, Mizusawa S, Okada Y, Ochiai M, Utsunomiya A, Koh KR, Ogata M, Nosaka K, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, Satake M, Okayama A, Mochizuki M, Izumo S, Saito S, Itabashi K, Kamihira S, Yamaguchi K, Watanabe T, Hamaguchi I.
Standardization of Quantitative PCR for Human T-cell Leukemia Virus Type 1 in Japan: A Collaborative Study.
J Clin Microbiol, 53(11):3485-3491, 2015.

Usuba A, Yamashiro T, Handa H, Matsuoka S, Yamano Y, Miyazawa T, Mineshita M.
Quantitative Computed Tomography Measurement of Tracheal Cross-Sectional Areas in Relapsing Polychondritis: Correlations with Spirometric Values.
Respiration, 90(6):468-473, 2015.

Ishihara M, Araya N, Sato T, Saichi N, Fujii R, Yamano Y, Sugano S, Ueda K.
A plasma diagnostic model of human T-cell leukemia virus-1 associated myelopathy.
Ann Clin Transl Neurol, 2(3):231-240, 2015.

Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara KI, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.
EMBO J, 34(8):1042-1055, 2015.

Shimizu J, Oka H, Yamano Y, Yudoh K, Suzuki N.
Cardiac involvement in relapsing polychondritis in Japan.
Rheumatology
, 55(3):583-584, 2016.

Usuba A, Handa H, Inoue T, Azagami S, Yamano Y, Mineshita M, Miyazawa T, Baumbach JI.
Breath analysis for relapsing polychondritis assessed by ion mobility spectrometry.
Int J Ion Mobil Spec, 18(3):177-183, 2015.

石塚賢治、山野嘉久、宇都宮與、内丸薫.
HTLV-1キャリア外来の実態調査.
臨床血液, 56(6):666-672, 2015.

山野嘉久. 
HTLV-1関連脊髄症(HAM)-分子病態解明による治療薬開発の新展開. 
医学のあゆみ, 255(5):485-490, 2015.

山野嘉久、新谷奈津美、八木下尚子、佐藤知雄. 
免疫性神経疾患-基礎・臨床研究の最新知見-. 
日本臨牀, 73(7):546-553, 2015.

山野嘉久.
日本初、希少難病HAMに対する革新的治療薬の開発.
ビオフィリア電子版, 4(2):43-49, 2015.

山野嘉久.
HTLV-1関連脊髄症(HAM).
難病事典, 編集責任:尾崎承一, 2-5/511, 2015.

2014

Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y.
HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.
J Clin Invest, 124(8):3431-3442, 2014.

Coler-Reilly A, Ando H, Yamano Y.
Positive feedback loop via astrocytes causes chronic inflammation in human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.
Clin Exp Neuroimmunol, 5(108-109),2014. 

Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD.
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis.
Genes Dev, 28(7):708-22, 2014.

Sato T., Yamano Y., Tomaru U., Shimizu Y., Ando H., Okazaki T,. Nagafuchi H., Shimizu J., Ozaki S., Miyazawa T., Yudoh K., Oka H., Suzuki N.
Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis.
Modern Rheumatology, 24(1): 129-136, 2014.  clip詳しくはコチラ

Suzuki N, Shimizu J, Oka H, Yamano Y, Yudoh K.
Neurological involvement of relapsing polychondritis in Japan: An epidemiological study.
Inflammation and Regeneration, 34(4):206-208, 2014.

Kawamata T, Ohno N, Sato K, Kobayashi M, Jo N, Yuji K, Tanosaki R, Yamano Y, Tojo A, Uchimaru K.
A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy.
SpringerPlus, 3:581, 2014.

山野嘉久.
HTLV-1関連脊髄症(HAM).
別冊日本臨牀 新領域別症候群シリーズ 神経症候群(第2版), 30:153-156, 2014.

山野嘉久.
HTLV-1の神経障害.
内科, 113(6):1431, 2014.

山野嘉久.
HTLV-1関連脊髄症(HAM)の分子病態に基づく治療戦略.
細胞, 46(6):258-261, 2014.

山野嘉久.
ヒト細胞白血病ウイルスⅠ型関連脊髄症.
神経関連感染症 最新医学 別冊, 200-205,最新医学社, 2014.

新谷奈津美、山野嘉久.
HTLV-1関連脊髄症(HAM)に対する分子標的治療薬開発の現状と将来.
血液内科, 68(1)30-35,  2014.

山野嘉久.
希少な慢性進行性の神経難病HAMにおける治療有効性評価モデルの探索. 
臨床評価 別冊, 41(3):504-508, 2014.

半田寛, 薄場彩乃, 岡本真理子, 井上哲兵, 延山誠一, 井上健男, 峯下昌道, 山野嘉久, 宮澤輝臣.
気道病変を有する再発性多発軟骨炎に対するチオトロピウムの効果.
聖マリアンナ医科大学雑誌 , 41(4):315-321, 2014.

2013

Ando H., Sato T., Tomaru U., Yoshida M., Utsunomiya A., Yamauchi J., Araya N., Yagishita N., Coler-Reilly A., Shimizu Y., Yudoh K., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Yamano Y.
Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy.
Brain, 136(Pt 9):2876-87, 2013. clip詳しくはコチラ

Sato T., Coler-Reilly A., Utsunomiya A., Araya N., Yagishita N., Ando H., Yamauchi J., Inoue E., Ueno T., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Izumo S., Yamano Y.
CSF CXCL10, CXCL9, and Neopterin as Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis.
PLoS Negl Trop Dis, 7(10): e2479, 2013.

Ishihara M., Araya N., Sato T., Tatsuguchi A., Saichi N., Utsunomiya A., Nakamura Y., Nakagawa H., Yamano Y., Ueda K.
Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia.
Blood, 121(21): 4340-4347, 2013. clip詳しくはコチラ

Tamai Y., Hasegawa A., Takamori A., Sasada A., Tanosaki R. Choi I., Utsunomiya A., Maeda Y., Yamano Y., Eto T., Koh K., Nakamae H., Suehiro Y., Kato K., Takemoto S., Okamura J., Uike N., Kannagi M.
Potential contribution of a novel Tax epitope-specific CD4+ T cells to graftversus-Tax effects in adult T-cell leukemia patients after allogeneic hematopoietic stem cell transplantation.
Journal of Immunology, 190(8):4382-4392, 2013. clip詳しくはコチラ

Grassi MF, Olavarria VN, Kruschewsky Rde A, Silva MT, Yamano Y, Jacobson S, Taylor GP, Martin F, Galvão-Castro B.
Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardisation.
J Clin Virol, 58(3): 584-6, 2013.

Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Okamura S, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K.
Vulnerability to traumatic stress in fibromyalgia patients: 19 month follow-up after the great East Japan disaster.
Arthritis Res  Ther, 15(5):R130, 2013.

Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Itoh K, Yamano Y, Nakamura H, Nakajima T, Nishioka K.
The Japanese version of the modified ACR Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale: reliability and validity.
Mod Rheumatol. 23(5):846-850, 2013. 

宇都宮與, 山野嘉久.
慢性型ATLの自然寛解後にHTLV-1関連脊髄症を発症した症例.
血液フロンティア, 23(3): 5(301)-10(306), 2013.

山内淳司、八木下尚子、安藤仁、佐藤知雄、新谷奈津美、Ariella, Coler-Reilly、今井直彦、中澤龍斗、佐々木秀郎、柴垣有吾、安田隆、力石辰也、木村健二郎、山野嘉久.
Human T-lymphotropic virus type 1感染者における腎移植の影響.
日本臨床腎移植学会雑誌,  1(1), 55-60, 2013.

山野嘉久、佐藤知雄、宇都宮與. 
白血病 非定型白血病および特殊型 HTLV-1関連脊髄症(HAM). 
別冊日本臨牀 新領域別症候群シリーズ 血液症候群(第2版), 23(Ⅲ):195-199, 2013.

山野嘉久、他.
線維筋痛症診療ガイドライン2013
日本線維筋痛症学会編, 全219ページ, 日本医事新報社, 2013.

山野嘉久、佐藤知雄 
HTLV-1関連脊髄症(HAM)の病態・治療とバイオマーカー
日本臨牀, 71(5):870-875, 2013.

山野嘉久
HAM(HTLV-1関連脊髄症)
すべての内科医が知っておきたい神経疾患の診かた、考え方とその対応, 279-281, 2013.

2012

Yamano Y., Sato T.
Clinical pathophysiology of human T-lymphotropic virus-type1-associated myelopathy/tropical spastic paraparesis
Front Microbiol  3(389):1-10, 2012.    clip詳しくはコチラ

Yagishita N., Aratani S., Leach C., Amano T., Yamano Y., Nakatani K., Nishioka K. and Nakajima T.
RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis.
Int. J. Mol. Med  30:1281-1286, 2012.     clip詳しくはコチラ

Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Ito K, Yamano Y, Nakamura H, Nakajima T, Nishioka K.
The Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale: reliability and validity.
Mod Rheumatol  22(1):40-44, 2012.    clip詳しくはコチラ

山野嘉久、佐藤知雄、安藤仁、新谷奈津美、八木下尚子
HTLV-1関連脊髄症(HAM)の治療法を確立していくために―その現状と展望―
日本臨牀  70(4):705-713, 2012. 

Fujii R, Komatsu R, Sato T, Yagishita N, Araya N, Aratani S, Nishikawa H, Yamano Y, Yudoh K, Beppu M, Nishioka K, Nakajima T.
Analysis of a Core Promoter Context of Synoviocyte Proliferation-Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.
J St. Marianna Univ 2012; 40: 51-56, 2012.

〔症例報告〕
大石裕樹,安藤仁,高橋昌明,高濱宗一郎,喜安純一,南留美,石橋誠,山本政弘
エファビレンツ、テノホビル/エムトリシタビンを大量服用した症例の血中濃度推移について.
日本エイズ学会誌. 14(1), 42-45, 2012.

2011

Araya N, Sato T, yagishita N, Ando H, Utsunomiya A, Jacobson S, Yamano Y. 
Human T-Lymphotropic Virus Type 1 (HTLV-1) and Regulatory T Cells in HTLV-1-Associated Neuroinflammatory Disease.
Viruses 3:1532-1548, 2011.     clip詳しくはコチラ

Sato T, Fujii R, Konomi K, Yagishita N, Aratani S, Araya N, Aono H, Yudoh K, Suzuki N, Beppu M, Yamano Y, Nishioka K, Nakajima T. 
Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans.
Arthritis Rheum  63 (12): 3833-3842, 2011.     clip詳しくはコチラ

Araya N, Takahashi K, Sato T, Nakamura T, Sawa C, Hasegawa D, Ando H, Aratani S, Yagishita N, Fujii R, Oka H, Nishioka K, Nakajima T, Mori N and Yamano Y.
Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type1-associated neurological disease.
Antivir Ther 16 (1): 89-98, 2011.

Sato T, Konomi K, Fujii R, Aono H, Aratani S, Yagishita N, Araya N, Yudoh K, Beppu M, Yamano Y, Nishioka K and Nakajima T.
Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.
Ann Rheum Dis 70 (1): 221-226, 2011.     clip詳しくはコチラ

Sato T., Araya N., Yagishita N., Ando H., Yamano Y.
Host Immune System Abnormalities Among Patients with Human T-Lymphotropic Virus Type 1 (HTLV-1)- Associated Disorders.
T-Cell Leukemia 65-80/234, InTech, 2011, Oct.

Takamori A., Hasegawa A., Utsunomiya A., Maeda Y., Yamano Y., Masuda M., Shimizu Y., Tamai Y., Sasada A., Zeng N., Choi I., Uike N., Okamura J., Watanabe T.,  Masuda T., Kannagi M.
Functional impairment of Tax-specific but not cytomegalovirus-specific CD8+ cytotoxic T lymphocytes in a minor population of asymptomatic human T-cell leukemia virus type 1-carriers.
Retrovirology  2011 7(8):100(1-15), 2011 Dec.

Kitazono T., Araya N., Yamano Y., Yamada Y., Nakamura T., Tanaka Y., Inoue M., Ozaki S. Corresponding Author:Okazaki T.
Advantage of higher-avidity CTL specific for Tax against human T-lymphotropic virus-1 infected cells and tumors.
Cellular Immunology 272(1):11-17, 2011 Oct.

Sato T, Azakami K, Ando H, Araya N and Yamano Y.
Human T-lymphotropic virus type 1 (HTLV-1) and innate immunity.
Inflammation and Regeneration 31 (1): 110-115, 2011.

山野嘉久、佐藤知雄、新谷奈津美、安藤仁、八木下尚子
HAM専門外来の取り組み
神経内科 75(4)387-392, 2011.

鈴木登、遊道和雄、岡寛、山野嘉久
再発性多発軟骨炎
リウマチ科 45(5):510-514, 2011.

山野嘉久 
HTLV-1キャリアー,HTLV-1-associated myelopathy(HAM)患者診療の現状と問題点
血液内科 63(1):81-86, 2011.

安藤仁、八木下尚子、新谷奈津美、佐藤知雄、山野嘉久 
HTLV-1関連脊髄症(HAM)の病態と治療
医療と検査機器・試薬 34(4):472-477, 2011.

山野嘉久、他21名.
線維筋痛症と神経内科的疾患の鑑別.
線維筋痛症診療ガイドライン2011, 日本線維筋痛症学会編, 65-69, 2011年, 日本医事新報社.

2010

Yamano Y and Nishioka K.
The contribution of Asian researchers to the field of rheumatology.
Nat Rev Rheumatol 6 (2): 106-111, 2010.

Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koike J, Tadokoro M, Suzuki N, Nagata K, Senoo H, Friedman SL, Nishioka K, Yamano Y, Itoh F and Nakajima T.
E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis.
PLoS One 5 (10): e13590, 2010.

Yamano Y and Jacobson S.
HTLV-1 infected CD4+CD25+CCR4+T-cells disregulate balance of inflammation and tolerance in HTLV-1 associated neuroinflammatory disease.
Immunologic Signatures of Rejection 1st Edition, 189-198, Springer Science, 2010.

Matsuura E, Yamano Y and Jacobson S.
Neuroimmunity of HTLV-I Infection.
J Neuroimmune Pharmacol 5 (3): 310-325, 2010.

Kamihira S, Yamano Y, Iwanaga M, Sasaki D, Satake M, Okayama A, Umeki K, Kubota R, Izumo S, Yamaguchi K and Watanabe T.
Inter-and intra-laboratory Variability in HTLV-1 Proviral Load Quantification Using Real-Time Polymerase Chain Reaction Assays: A Multi-Center Study.
Cancer Sci 101 (11): 2361-2367, 2010.

Omurzakova NA, Yamano Y, Saatova GM, Alybaeva MS, Nishioka K, Nakajima T.
Prevalence of Group A b-Hemolytic Streptococcus Among Children with Tonsillopharyngitis in Kyrgyzstan: The Difficulty of Diagnostics and Therapy.
Open Rheumatol J 13;4:39-46, 2010.

岡寛、山野嘉久、遊道和男、鈴木登、須賀万智
再発性多発軟骨炎の全国疫学調査
リウマチ科 44 (3): 381-383, 2010.

佐藤知雄、中島利博、山野嘉久
プロスタグランジン関連分子標的薬---とくに抗炎症薬について
日本臨床 68 (10): 1835-1839, 2010.

2009

Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, Hasegawa D, Izumi T, Fujita H, Aratani S, Fujii R, Yagishita N, Kamijyuku H, Kanekura T, Seino K, Nishioka K, Nakajima T and Yamano Y.
Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients withHTLV-1-associated disorders.
Blood 114 (15): 3208-3215, 2009.

Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, Hasegawa D, Izumi T, Fujita H, Aratani S, Yagishita N, Fujii R, Nishioka K, Jacobson S and Nakajima T.
Abnormally high levels of virus- infected IFN-γ+CCR4+CD4+CD25+ T cells in a retrovirus-associated neuroinflammatory disorder.
PLoS One 4 (8): e6517, 2009.

Shimizu Y, Takamori A, Utsunomiya A, Kurimura M, Yamano Y, Hishizawa M, Hasegawa A, Kondo F, Kurihara K, Harashima N, Watanabe T, Okamura J, Masuda T and Kannagi M.
Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages.
Cancer Sci 100 (3): 481-489, 2009.

Izumi T, Fujii R, Nakazawa M, Yagishita N, Tsuchimochi K, Yamano Y, Sato T, Fujita H, Aratani S, Araya N, Azakami K, Hasegawa D, Kasaoka S, Tsuruta R, Yokouti M, Ijiri K, Beppu M, Maruyama I, Nishioka K, Maekawa T, Komiya S and Toshihiro Nakajima T.
Activation of Synoviolin Promoter in Rheumatoid Synovial Cells by a Novel Transcription Complex of Interleukin Enhancer Binding Factor 3 and GA Binding Protein.
Arthritis Rheum 60 (1): 63-72, 2009.

Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T and  Komano H.
An E3 ubiquitin ligase, Synoviolin is involved in the degradation of immature Nicastrin, and regulates the production of amyloid β-protein.
FEBS J 276 (20): 5832-5840, 2009.

Omurzakova NA, Yamano Y, Saatova GM, Shukurova SM, Mirzakhanova MI, Kydyralieva RB, Jumagulova AS, Mirrakhimov EM, Seisenbaev ASh, Nishioka K, Nakajima T.
Rheumatologic services in Central Asian countries: current state of development of rheumatology in Central Asia.
Int J Rheum Dis Dec;12(4):288-92, 2009.

Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I and Nakajima T.
A role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.
Int J Mol Med 24 (5) :605-611, 2009.

Omurzakova NA, Yamano Y, Saatova GM, Mirzakhanova MI, Shukurova SM, Kydyralieva RB, Jumagulova AS, Seisenbaev ASh, Nishioka K and Nakajima T.
High incidence of rheumatic fever and rheumatic heart disease in the republics of Central Asia.
Int J Rheum Dis 12 (2): 79-83, 2009.

新谷奈津美、佐藤知雄、加藤智啓、山野嘉久
T細胞の分化・成熟機構
血液・腫瘍科 58 (6): 631-639, 2009.

吉福明日香、植木ゆり、玉井真理子、三好逸男、東裕子、金蔵拓郎、山野嘉久
髄膜脳炎を合併した帯状疱疹の1例
西日本皮膚科 71 (5): 494-496, 2009.

2008

Grant C, Oh U, Yao K, Yamano Y and Jacobson S.
Dysregulation of TGF-beta signaling and regulatory and effector T cell function in virus-induced neuroinflammatory disease.
Blood 111 (12): 5601-5609, 2008.

Yagishita N, Yamasaki S, Nishioka K and Nakajima T.
Synoviolin, protein folding and the maintenance of joint homeostasis.
Nature Clin Prac Rheum 4 (2): 91-7, 2008.

Imaizumi T, Arikawa T, Sato T, Uesato R, Matsumiya T, Yoshida H, Ueno M, Yamasaki S, Nakajima T, Hirashima M, Sakata K, Ishibashi Y, Toh S, Ohyama C and Satoh K.
Involvement of retinoic acid-inducible gene-I in inflammation of rheumatoid fibroblast-like synoviocytes.
Clin Exp Imunol 153 (2): 240-244, 2008

Omurzakova NA, Yamano Y, Sato T, Izumi T, Azakami K, Hasegawa D, Fujii R, Yagishita N, Aratani S, Kabaeva ZS, Mirrakhimov MM, Kami M, Maruyama I, Osame M, Yokota S, Nishioka K and Nakajima T.
Increased prevalence of group A b-hemolytic streptococcus among an ethnic population in Kyrgyzstan detected by the rapid antigen detection test.
Mol Med Report 1 (6): 869-874, 2008.

Aratani S, Kageyama Y, Nakamura A, Fujita H, Fujii R, Nishioka K and Nakajima T.
MLE activates transcription via the minimal transactivation domain in Drosophila.
Int J Mol Med 21 (4): 469-476, 2008.

山野嘉久、ナズグル オムルザコワ、西岡久寿樹、中島利博
現代キルギスの健康問題の一側面
世界の発酵乳 84-91, 2008.

山野嘉久
HTLV-1ウイルスと免疫の関係
教えて!HTLV-1のこと 169-181, 2008

2007

Puccioni-Sohler M, Yamano Y, Rios M, Carvalho SMF, Vasconcelos CCF, Alvarenga RP and Jacobson S.
Differentiation of HAM/TSP from patients with multiple sclerosis infected with HTLV-I.
Neurology 68 (3): 207-213, 2007.

Yamasaki S, Yagishita N, Nishioka K and Nakajima T.
The roles of Synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway.
Cell Cycle 6 (11): 1319-1323, 2007.

Wu W, Nishikawa H, Hayami R, Sato K, Honda A, Aratani S, Nakajima T, Fukuda M and Ohta T.
BRCA1 Ubiquitinates RPB8 in Response to DNA Damage.
Cancer Res 67 (3): 951-58, 2007.

Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, Bae E, Toriyama S, Ikeda R, Zhang L, Fujitani K, Yoo E, Tsuchimochi K, Ohta T, Araya N, Fujita H, Aratani S, Eguchi K, Komiya S, Maruyama I, Higashi N, Sato M, Senoo H, Ochi T, Yokoyama S, Amano T, Kim J, Gay S, Fukamizu A, Nishioka K, Tanaka K, Nakajima T.
Cytoplasmic destruction of p53 by theendoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’
EMBO J 26 (1): 113-122, 2007.

山野嘉久、尾崎承一
Wegener肉芽腫症
総合臨床 56: 1529-1535, 2007.

佐藤知雄、八木下尚子、西岡久寿樹、中島利博
関節リウマチ制御の新規標的分子
炎症と免疫 15 (6): 25-29, 2007.

八木下尚子、中島利博
シノビオリンと関節リウマチ
最新医学 62 (6): 1226-31, 2007.

中島利博
私が名付けた遺伝子シノビオリンその滑らかな音色とともに
実験医学 25 (3): 2007.

2006

Yao K, Hisada M, Maloney E, Yamano Y, Hanchard B, Wilks R, Rios M and Jacobson S.
Human T lymphotropic virus type I and II western blot seroindeterminate and its association with exposure to prototype HTLV-I.
J Infect Dis 193 (3): 427-437, 2006.

Maloney EM, Yamano Y, Vanveldhuisen PC, Sawada T, Kim N, Cranston B, Hanchard B, Jacobson S and Hisada M.
Natural history of viral markers in children infected with human T lymphotropic virus type I in Jamaica.
J Infect Dis 194 (5): 552-560, 2006.

Aratani S, Oishi T, Fujita H, Nakazawa M, Fujii R, Imamoto N, Yoneda Y, Fukamizu A and Nakajima T.
The nuclear import of RNA helicase A is Mediated by importin-α3.
Biochem Biophys Res Commun 340 (1): 125-133, 2006.

Sato T, Konomi K, Yamasaki S, Aratani A, Tsuchimochi K, Yokouchi M, Masuko-Hongo K, Yagishita N, Nakamura H, Komiya S, Beppu M, Nishioka K and Nakajima T.
Comparative Analysis of Gene Expression Profiles in Intact Versus Damaged Regions of Human Osteoarthritic Cartilage.
Arthritis Rheum 54 (3): 808-817, 2006.

Yagishita N, Yamasaki S, Nishioka K and Nakajima T.
Role of Synoviolin in rheumatoid arthritis: possible clinical relevance.
Future Rheumatology 1(1): 31-36, 2006.

Yamasaki S, Yagishita N, Tsuchimochi K, Kato Y, Sasaki T, Amano T, Beppu M, Aoki H, Nakamura H, Nishioka K and Nakajima T.
Resistance to endoplasmic reticulum stress is an acquired cellular characteristic of rheumatoid synovial cells.
Int J Mol Med 18 (1): 113-117, 2006.

八木下尚子、中島利博
ERAD (ER associated degradation)亢進症としての関節リウマチ
ホルモンと臨床 54 (9): 75-79, 2006.

八木下尚子、中島利博
シノビオリンと関節リウマチ
蛋白質核酸酵素 51 (10): 1298-1303, 2006.

八木下尚子、西岡久寿樹、中島利博
滑膜細胞の秘めたポテンシャル
分子リウマチ 3 (3): 47-54, 2006.

中島利博
オピニオン(対談)
バイオテクノジージャーナル 6 (2): 131, 2006.

杉浦明子、八木下尚子、中島利博
滑膜細胞増殖制御の鍵を握る新規因子:シノビオリン
リウマチ科 34 (3): 336-340, 2006.

2005

Yamano Y, Takenouchi N, Li HC, Tomaru U, Yao K, Grant CW, Maric DA and Jacobson S.
Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease.
J Clin Invest 115 (5): 1361-1368, 2005.

Oh U, Yamano Y, Mora CA, Ohayon J, Bagnato F, Butman JA, Dambrosia J, Leist TP, McFarland H and Jacobson S.
Interferon-beta 1a therapy in human-T-lymphotropic virus type-I associated neurologic disease.
Ann Neurol 57 (4): 526-534, 2005.

Bagnato F, Butman J., Mora CA, Gupta S, Yamano Y, Tasciyan TA, Solomon JM, Santos WJ, Stone RD, McFarland HF and Jacobson S.
Conventional magnetic resonance imaging features in patients with tropical spastic paraparesis.
J Neurovirol 11 (6): 525-534, 2005.

Yamasaki S, Yagishita N, Tsuchimochi K, Nishioka K, and Nakajima T.
Rheumatoid Arthritis as a hyper-endoplasmic reticulum-associaetd degradation disease.
Arthritis Res Ther 7 (5): 181-186, 2005.

Tsuchimochi K, Yagishita N, Yamasaki S, Amano T, Kato Y, Kawahara K, Aratani S, Fujita H, Ji FY, Sugiura A, Izumi T, Sugamiya A, Maruyama I, Fukamizu A, Komiya S, Nishioka K and Nakajima T.
Identification of a crucial site for Synoviolin expression.
Mol Cell Biol 25 (16): 7344-56, 2005.

Fujita H, Ohshima T, Ohishi T, Aratani S, Fujii R, Fukamizu A, and Nakajima T.
Relevance of nuclear localization and functions of RNA helicase A.
Int J Mol Med 15 (4): 555-560, 2005.

Yagishita N, Ohneda K, Amano T, Yamasaki S, Sugiura A, Tsuchimochi K, Shin H, Kawahara K, Ohneda O, Ohta T, Tanaka S, Yamamoto M, Maruyama I, Nishioka K,Fukamizu A and Nakajima T.
Essential Role of Synoviolin in Embryogenesis.
J Biol Chem 280 (9): 7909-7916, 2005.

菅宮朝子、八木下尚子、中島利博
関節リウマチとシノビオリン
Medical Technology 33 (4): 341-344, 2005.

泉俊彦、八木下尚子、西岡久寿樹、中島利博、土持兼之、小宮節郎
関節ホメオスタシスのregulator:シノビオリン
THE BONE 19 (6): 49-58, 2005.

八木下尚子、中島利博
新規関節リウマチ病因遺伝子シノビオリン
リウマチ科 34 (2): 214-220, 2005.

土持兼之、八木下尚子、中島利博
シノビオリン転写制御と滑膜細胞恒常性維持
Molecular Medicine 42 (9): 995-1000, 2005.

加藤幸裕、山崎聡士、八木下尚子、土持兼之、中島利博
膠原病研究の進歩 関節リウマチの滑膜増殖機構
臨床免疫学(下) 63(増刊5): 199-204, 2005.

2004

Yamano Y, Cohen CJ, Takenouchi N, Yao K, Tomaru U, Li HC, Reiter Y and Jacobson S.
Increased Expression of Human T Lymphocyte Virus Type I (HTLV-I) Tax11-19 Peptide-Human Histocompatibility Leukocyte Antigen A*201 Complexes on CD4+ CD25+ T Cells Detected by Peptide-specific, Major Histocompatibility Complex-restricted Antibodies in Patients with HTLV-I-associated Neurologic Disease.
J Exp Med 199 (10): 1367-1377, 2004.

Monsurro V, Wang E, Yamano Y, Migueles SA, Panelli MC, Smith K, Nagorsen D, Connors M, Jacobson S and Marincola FM.
Quiescent phenotype of tumor-specific CD8+ T cells following immunization.
Blood 104 (7): 1970-1978, 2004.

Daitoku H, Hatta M, Matsuzaki H, Aratani S, Ohshima T, Miyagishi M, Nakajima T and Fukamizu A.
Sir2 potentiates Foxo1-mediated transcription via its deacetylase.
Proc Natl Acad Sci USA 101(27): 10042-10047, 2004.

Nakajima T, Aratani S, Nakazawa M, Hirose T, Fujita H and Nishioka K.
Implications of transcriptional coactivator CREB binding protein complexes in rheumatoid arthritis.
Mod Rheumatol 14 (1): 6-11, 2004.

山野嘉久
HTLV-IによるCD4+CD25+制御性T細胞の抑制機能低下~レトロウイルスは自己免疫疾患を引き起こす?
臨床免疫 42 (3): 341-345, 2004.

外丸詩野、山野嘉久、吉木 敬
ペプチド/HLA複合体の抗原特異的T細胞による獲得:新たなHTLV-I特異的T細胞の検出法
血液フロンティア 14 (1): 49-58, 2004.

八木下尚子、中島利博
関節リウマチとシノビオリン
感染・炎症・免疫 34 (4): 64-66 ,2004.

八木下尚子、山崎聡士、天野徹也、土持兼之、加藤幸裕、西岡久寿樹、中島利博
シノビオリンによる滑膜細胞増殖とその人為的制御
臨床免疫 42 (5): 541-546, 2004.

土持兼之、中島利博
OAと滑膜
医学のあゆみ 211 (4): 289-293, 2004.

八木下尚子、中島利博
関節リウマチ発症の病因分子シノビオリン
医学のあゆみ 211 (1): 124-128, 2004.

中島利博
研究生活の因果は巡る
癌と人 31: 33-34, 2004.

荒谷聡子、藤井亮爾、藤田英俊、中島利博
HIV遺伝子発現に関与する宿主システムの解明
臨床薬理の進歩 25: 120-125, 2004.

荒谷聡子、中島利博
滑膜細胞増殖と転写因子
医学のあゆみ 209 (10): 765-769, 2004.

中島利博
研究生活の因果は巡る―15年間の研究生活を振り返って―
聖マリアンナ医科大学雑誌 32 (1): 2004.

天野徹也、中島利博
関節リウマチ発症に関わる新たなる因子シノビオリン
Bioベンチャー 3 (4): 54-55, 2004.

2003

Tomaru U*, Yamano Y*, Nagai M, Maric D, Kaumaya P, Biddison W and Jacobson S. (*equally contributed first author)
Detection of virus-specific T cells and CD8+ T-cell epitopes by acquisition of peptide-HLA-GFP complexes: analysis of T-cell phenotype and function in chronic viral infections.
Nat Med 9 (4): 469-475, 2003.

Cohen CJ, Sarig O, Yamano Y, Tomaru U, Jacobson S and Reiter Y.
Direct Phenotypic Analysis of Human MHC Class I Antigen Presentation: Visualization, Quantitation, and In Situ Detection of Human Viral Epitopes Using Peptide-Specific, MHC-restricted Human Recombinant Antibodies.
J Immunol 170 (8): 4349-4361, 2003.

Yamano Y, Tomaru U and Jacobson S.
Role of HTLV-I specific CTL in HAM/TSP.
Gann Monograph on Cancer Reserch 50: 171-182, 2003.

Takenouchi N, Yamano Y, Usuku K, Osame M and Izumo S.
Usefulness of proviral load measurement for monitoring of disease activity in individual patients with human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis.
J Neurovirol 9 (1): 29-35, 2003.

Abeyama K, Kawahara K, Iino S, Hamada T, Arimura S, Matsushita K, Nakajima T and Maruyama I.
Antibiotic cyclic AMP signaling by "primed" leukocytes confers anti-inflammatory cytoprotection.
J Leukoc Biol 74 (5): 908-115, 2003.

Aratani S, Fujii R, Fujita H, Fukamizu A and Nakajima T.
Aromatic residues are required for RNA helicase A mediated transactivation.
Int J Mol Med 12 (2): 175-180, 2003.

Araya N, Hirota K, Shimamoto Y, Miyagishi M, Yoshida E, Ishida J, Kaneko S, Kaneko M, Nakajima T and Fukamizu A.
Cooperative Interaction of EWS with CREB -binding Protein Selectively Activates Hepatocyte Nuclear Factor 4-mediated Transcription.
J Biol Chem 278 (7): 5427-5432, 2003.

Taniguchi N, Kawahara K, Yone K, Hashiguchi T, Yamakuchi M, Goto M, Inoue K, Yamada S, Ijiri K, Matsunaga S, Nakajima T, Komiya S and Maruyama I.
High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine.
Arthritis Rheum 48 (4): 971-981, 2003.

Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K and  Nakajima T.
Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP.
Int J Mol Med 11 (6): 705-712, 2003.

Fujita H, Fujii R, Aratani S, Amano T, Fukamizu A and Nakajima T.
Antithetic effects of MBD2a on gene regulation.
Mol Cell Biol 23 (8): 2645-2657, 2003.

Kawahara K, Kawabata H, Aratani S and Nakajima T.
Hyper nuclear acetylation (HNA) in proliferation, differentiation and apoptosis.
Ageing Res Rev 2 (3): 287-297, 2003.

Nakajima T.
Novel therapeutic target identified in fight against rheumatoid arthritis.
Science Daily (Cold Spring Harbor Laboratory) 2003-9-17, 2003.

Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zheng L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I,fukamizu A and Nakajima T.
Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy.
Genes Dev 17(19): 2436-2449, 2003.

八木下尚子、中島利博
関節リウマチの発症の鍵を握る分子:シノビオリン
細胞工学 22 (12): 1352-1353, 2003.

荒谷聡子、中島利博
転写とリウマチ
整形外科の最新医療 22: 120-125, 2003.

山崎聡士、土持兼之、中島利博
滑膜細胞のネイチャー
医学のあゆみ 205 (3): 213-5, 2003.

座談会 司会 中島利博  出席者 田中栄、妻木範行、高柳広
運動器科学の黎明
カレントテラピー 21(3): 80-87, 2003.

山崎聡士、西岡久寿樹、中島利博
“Bone and Joint Decade”運動器疾患の研究に新しい展開は可能か?
細胞工学 22 (1): 86-87, 2003.

山崎聡士、土持兼之、中島利博
総合科学としての運動器科学
カレントテラピー 21(3): 8-11, 2003.

2002

Yamano Y, Nagai M, Brennan M, Mora CA, Soldan SS, Tomaru U, Takenouchi N, Izumo S, Osame M and Jacobson S.
Correlation of human T-cell lymphotropic virus type I (HTLV-I) mRNA with proviral DNA load, virus-specific CD8+ T cells, and disease severity in HTLV-I-associated myelopathy (HAM/TSP).
Blood 99 (1): 88-94, 2002.

Ohkubo R, Nakagawa M, Ikeda K, Kodama T, Arimura K, Akiba S, Saito M, Ookatsu Y, Atsuchi Y, Yamano Y and Osame M.
Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders.
J Neurol Sci 198 (1-2): 31-35, 2002.

Nishimura S, Maeno N, Matsuo K, Nakajima T, Kitajima I, Saito H and Maruyama I.
Human lactiferous mammary gland cells produce vascular endothelial growth factor (VEGF) and express the VEGF receptors, Flt-1 and KDR/Flt-1.
Cytokine 18 (4): 191-198, 2002.

Nakazawa M, Aratani S, Hatta M, Araya N, Daitoku H, Kawahara K, Watanabe S, Nakamura H, Yoshino S, Fukamizu A, Nishioka K and Nakajima T.
TNFα induces acetylation of p53 but attenuates its transcriptionalactivation in rheumatoid synoviocytes.
Int J Mol Med 10 (3): 269-275, 2002.

Imaizumi T, Aratani S, Nakajima T, Carlson M, Matsumiya T, Tanji K, Ookawa K, Yoshida H, Tsuchida S, McIntyre TM, Prescott SM, Zimmerman GA and Satoh K.
Retinoic Acid-Inducible Gene-I Is Induced in Endothelial Cells by LPS and Regulates Expression of COX-2.
Biochemi Biophys Res Commun 292 (1): 274-279, 2002.

Nquyen NC, Nakamura H, Nakazawa M, Hirose T, Kobata T, Nishioka K and Nakajima T.
Expression of HOXD9 in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Int J Mol Med 10 (1): 41-48, 2002.

Kitagawa H, Yanagisawa J, Fuse H, Ogawa S, Yogiashi Y, Okuno S, Nagasawa H, Nakajima T Matsumoto T and Kato S.
Ligand Selective Potentiation of Rat Mineralocorticoid Receptor Activation Function-1 (AF-1) by ACBP-containing HAT complex.
Mol Cell Biol 22 (11): 3698-3706, 2002.

Kawabata H, Kawahara K, Kanekura T, Araya N, Daitoku H, Hatta M, Miura N, Fukamizu A, Kanzaki T, Maruyama I and Nakajima T.
Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium induced keratinocyte differentiation.
J Biol Chem 277 (10): 8099-8105, 2002.

特許

PCT出願:PCT/JP2018/1301、発明者:荒木一司、山野嘉久、新谷奈津美、出願人:第一三共株式会社、出願日:2018/1/16、HTLV-1関連脊髄症を治療することに用いるための医薬組成物

特願2017-171605、発明者:山野嘉久(聖マリアンナ医科大学)、東久世裕太、永井豪(以上、協和メデックス)、出願人:聖マリアンナ医科大学、協和メデックス株式会社、出願日:2017年9月6日、ヒトT細胞白血病ウイルス1型(HTLV-1)プロウイルスDNAの測定方法および測定キット

特願2017-039506、発明者:山野嘉久、出願人:学校法人聖マリアンナ医科大学、協和発酵キリン株式会社、出願年月日:2017年3月2日、低用量抗CCR4抗体を用いたHTLV-1関連脊髄症の予防または治療剤
PCT出願:PCT/JP2018/008166, 出願日:2018/3/2

特願2017-007887、発明者:荒木一司(第一三共株式会社)、山野嘉久、新谷奈津美、出願年月日:2017年1月19日、HTLV-1関連脊髄症を治療することに用いるための医薬組成物

特願2016-158190、発明者:山野嘉久、張黎臨、出願年月日:2016年8月10日、HTLV-1関連炎症性疾患を治療する医薬組成物

特許番号:第5963233号、登録日:2016年7月8日、特願2011-268019、発明者:山野嘉久、安藤仁、佐藤知雄、出願年月日:2011年12月7日、HAM(HTLV-Ⅰ関連脊髄症)に対する抗CXCL10抗体療法 HTLV-1関連脊髄症を治療または予防するための医薬および前記医薬を用いた抗体療法の治療効果の確認方法

PCT出願:PCT/JP2015/78911, 出願日:2015/10/13, Yoshihisa Yamano, Ken-ichiro Seino, Masato Muto, 出願人:St.Marianna University School of Medicine, Production method of gamma delta T cell and use thereof (γδT細胞の製造方法および医薬)

特願2014-226719、発明者:山野嘉久、植田幸嗣、石原誠人、出願年月日:2014年11月7日、ヒトTリンパ好性ウイルス-1(HTLV-1)関連脊髄症(HAM/TSP)の検査方法、及び検査用キット

特願2014-209669、発明者:山野嘉久、清野研一郎、武藤真人、出願年月日:2014年10月14日、γδT細胞の製造方法および医薬

特許番号:第5552630号、、特許公報:特開2010-100578、登録日:2014年6月6日、
出願番号:特願2008-274514、発明者:山野嘉久、新谷奈津美、出願年月日(2008年10月24日)
HTLV-I関連脊髄症を治療または予防するための医薬、およびHTLV-I関連脊髄症の患者に対する抗体療法の効果を試験する方法  
↓に変更
HAM(HTLV-Ⅰ関連脊髄症)に対する抗CCR4抗体療法
H3084日付で本学より協和発酵キリン様へ特許移転登録完了。

特願2013-121694、発明者:中島利博、荒谷聡子、臼井千恵、山野嘉久、西岡健弥、藤田英俊、八木下尚子、伊藤健司、中村郁朗、西岡久寿樹、出願年月日:2013年6月10日、小胞体ストレスシグナルを抑制することによる,薬剤の副作用としての体重増加や肥満を防止するために用いられる肥満防止剤

特許番号:第5499405号、登録日:2013年3月20日、
出願番号:特願2010-126487、発明者:山野嘉久、鈴木登、出願年月日(2010年6月2日)、
再発性多発軟骨炎の検査方法およびそれに用いられる検査キット

特願2012-189318、発明者:植田幸嗣、石原誠人、山野嘉久、出願年月日(2012年8月29日)、ヒトTリンパ球向性ウイルスI型関連疾患検出用ポリペプチドとその利用 

US61/668,686、Yoshihisa Yamano、出願年月日(2012年7月6日)、HAM(HTLV-Ⅰ関連脊髄症)に対する抗CCR4抗体療法の少量ステロイド併用による有効性と安全性の向上〔英文名称:A Therapeutic Method And Medicament For HTLV-1 Associated Myelopathy(HAM)〕
↓に変更
PCT出願:PCT/JP2013/068296 出願日:2013/7/3、米国出願:US13/936,290, 2013/7/8、国際公開№:WO2014/007303、Yoshihisa Yamano、HTLV-1関連脊髄症患者の治療方法および治療剤、出願人(権利者):聖マリアンナ医大、共同出願者:協和発酵キリン
英文名称:A THERAPEUTIC METHOD AND MEDICAMENT FOR HTLV-Ⅰ ASSOCIATED MYELOPATH(HAM)〕

61/391,094. Yoshihisa Yamano, Kusuki Nishioka. Diagnostic Agent for Fibromyalgia, Method For  Diagnosingfibromyalgia and Medicament for Fibromyalgia. 8 Oct 2010

特願2010-240868、発明者:山野嘉久、清野研一郎、出願年月日(2010年10月27日)、γδT
細胞の製造方法および医薬

特願2010-94641、発明者:山野嘉久、佐藤知雄、新谷奈津美、出願年月日(2010年4月16日)
HTLV-I関連脊髄症の予防及び/又は治療のための医薬

特願2008-180580、発明者:山野嘉久、出願年月日(2008年7月10日)
自己免疫疾患の病因細胞の分離方法および自己免疫疾患の診断補助方法

E-084-2003/0-US-01. Steven Jacobson, Utano Tomaru, Yoshihisa Yamano. Detection
of Antigen-Specific T Cells and Novel T Cell Epitopes by Acquisition of Peptide/HLA-GFP 
Complexes. 24 Mar 2003